Neonatal Hepatitis B Prevention and Vaccination Program

GPs need to be aware of the Neonatal Hepatitis B Prevention and Vaccination Program NSW Health Policy Directive when treating pregnant women. This policy directive specifies the requirements for neonatal hepatitis B prevention and vaccination which includes screening of pregnant women for hepatitis B surface antigen, referral of HBsAg positive women to a hepatologist specialist service, treatment and follow-up of infants born to HBsAg positive women, vaccination of all infants against hepatitis B and reporting of neonatal hepatitis B vaccination program data.

  • Pregnant women with a viral load (ie ≤200,000IU/ml and liver function test ALT less than 40IU/L), may be managed either under the care of their GP or by a specialist liver clinic.
  • Neonates born to HBsAg positive mothers must be offered hepatitis B immunoglobulin (HBIG) within 12 hours of birth and a total of four doses of hepatitis B vaccine at birth, six weeks, four and six months of age.
  • All infants born to HBsAg positive mothers require follow-up serology 3-12 months after completion of their primary hepatitis B vaccination course (and not before nine months of age) to check if they are protected.
  • Infants with an anti-HBs level <10IU/mL or who are HBsAg positive should be referred to a local specialist service (e.g. Infectious Diseases Clinic at Sydney Children’s Hospital, Randwick) or the Paediatric Viral Hepatitis Network (at The Children’s Hospital, Westmead) for ongoing management.

 Click here to read the full Policy Directive.