Zostavax Contraindications update

Zostavax Contraindications – Update November 2017

NSW Health have provided an update on Zostavax Contraindications.

  • Zostavax is contraindicated in patients with severe immunocompromise.
  • Treatment with sulfasalazine is no longer a contraindication to Zostavax vaccination
  • If in doubt seek advice from a specialist or the NSW Immunisation Specialist Service on 1800 679 477 (1800 NSWISS)

In addition to being contraindicated for those with previous anaphylaxis to the vaccine or its components, it is vital all GPs are aware of the following CONTRAINDICATIONS, which include but are not limited to:

  • Primary or acquired immunodeficiency
  • Haematologic neoplasms: leukaemias, lymphomas, myelodysplastic syndromes • Post-transplant: solid organ (on immunosuppressive therapy), haematopoietic stem cell transplant (within 24 months)
  • Immunocompromised due to primary or acquired (including HIV/AIDS) immunodeficiency
  • Other significantly immunocompromising conditions Immunosuppressive therapy (current or recent)
  • Chemotherapy or radiotherapy
  • High-dose corticosteroids (≥20 mg of prednisone per day, or equivalent) for ≥14 days
  • All biologics and most disease-modifying anti-rheumatic drugs (DMARDs)

Further Information: